One of the most common problems faced by humans is aging and age-related diseases. We are living in the world where we are judged on our looks and appearance. This is one of the reasons why scientists are looking for the best ageless solutions.
For many years, researchers believed that calorie restriction is useful for delaying illness and extending lifespan in small animals. When it comes to humans, there is no evidence of this. Researchers don’t understand how calorie restriction slows the aging process.
According to David Sinclair, a professor of genetics, it was believed that calorie restriction slows the body down. It was unclear, whether it affects the number of heartbeats or creation of free radicals. This was a misconception; by restricting calorie we tell the body that it is not the time to move forward. Instead, it is time to repair the broken genes, combat free radicals, and preserve resources.
The professor thinks a component, nicotinamide adenine dinucleotide (NAD), can be helpful for copying the effects of calorie restriction. This compound is present in all living cells. A great thing about this is that there will be no need for decreasing calorie intake or starvation.
In a mice study, it was found that young mice had more levels of NAD than older mice. When the NAD levels in older mice were increased, they become more youthful.
In a recent paper, researchers showed how NAD works to reverse the aging process. In a water few drops of NAD was added. When the mice drank water, their levels of NAD boosted. In the first week, the scientists saw an apparent improvement in the gene repair and age reversal in muscle.
The researchers believe NAD is associated with DNA repair function. It is believed that when levels of NAD are increased, PARP1 is activated. However, when the levels of NAD are reduced, the levels of PARP1 is also decreased. This shows that both the compounds are interlinked.
Sinclair is ready to test this on humans and see whether reversing aging is possible in humans or not. A company MetroBiotech, co-founded by Sinclair has developed a capsule for the predecessor to NAD, nicotinamide mononucleotide (NMN). This compound can be easily found in foods such as cucumber, broccoli, edamame, and avocado.
It is decided to test it on 25 people. If the results are positive, then we can see a broader application and protect DNA from age-related damage.