Before prescribing a patient with drugs, it is important to keep in mind that there are certain gut bacteria which can affect the way drugs work.
It has been proved scientifically that the bacteria living in your gut have the ability to alter the chemical compositions of drugs which affects the way that they work. However, the possibility of this issue lacks any clarity. Today, a far-reaching survey of such interactions proposes that these bacteria can alter various drugs and it is the genetic structure of a patient’s microbiota which might predict one’s reaction to medications.
Every person differs from another in the way that they respond to medicines and drugs. This can be rather expensive, as well as dangerous owing to any delays in the treatment and the possible side effects. Although there has been a lot of evidence that has proved that the gut bacteria are responsible for these differences in the ways individuals react to drugs, the molecular mechanisms which are involved in such an interaction are still quite unknown.
According to an experiment carried out in which the scientists tried to measure the ability of about 76 bacteria from the human gut from various different kinds of clades to digest as many as 271 orally-administered medicines, it was certainly found out that most of the drugs were modified by various gut bacteria chemically. They further put together high-throughput analyses on the genetics with the method of mass spectrometry for the purpose of identifying systematically all of the microbial gene products which were responsible for metabolization of drugs. These enzymes coded by the microbiome were proved to be substantially and directly affecting the systemic, as well as the intestinal drug metabolism in mice. Thus, this can certainly explain the role of bacteria present in the human gut in the metabolizing of various drugs on the foundation of the contents of their genome.
These fundamental connections between the metabolic activities and the gene content of the microbiota do link the interpersonal capriciousness in various microbiomes to the relational variances in drug metabolism. And this has suggestions for drug development and medical therapy across various disease warnings. It is because of these gut bacteria that every medicinal drug has a different effect or reaction on every different patient.