For decades, researchers have indicated that Bisphenol A have linked many health diseases including abnormal reproduction, hormone instability and many types of cancers. Bisphenol A(BPA) is an organic synthetic compound that found in manufacture products, for example, canned food, water bottles and receipts. Recent animal study suggests that BPA are harmful toxicants and moreover threaten the lives of your dogs or cats.

In the journal, Science of the Total Environment, Dr. Cheryl Rosenfeld group indicated the level of BPA was almost three folds increased when dogs were fed BPA included canned food. What they did in their study is that they have fed either BPA free foods or canned foods in two weeks. Unlike BPA free packed food group (0.7 ± 0.15 ng/mL), BPA-dietary group had more BPA in dog’s blood serum (2.2 ± 0.15 ng/mL, P < 0.0001) meaning greater BPA in serum was associated with serum chemistry and microbiome changes. They also pointed out that this study may have implications beyond your loved one’s health. Potentially human who have lived with their dogs or other pets also have confronted similar problems for BPA as those pets share most part of environments with us.

According to high volume of studies, it has been revealed that toxic chemicals including BPA can cause epigenetic modification which is gene alternation throughout one’s life. One of mechanisms that BPA acts as epigenetic effect is that BPA induce demethylation of estrogen receptor (ESR1) promoter-associated CpG islands, consequently altered ESR1. If genes are demethylation, this gene steadily produce protein, in this case, estrogen receptor 1 which can elevate breast cancer incidents.

In this study, they found that even short term exposure to BPA can cause your dog’s blood serum change, DNA methylation and gut microbiome composition change.